Hardy-Weinberg equilibrium and genetic association study
نویسندگان
چکیده
منابع مشابه
Hardy Weinberg Equilibrium Testing and Interpretation: Focus on infection
Hardy-Weinberg equilibrium (HWE) holds when, in a closed population with random mating and without mutation and natural selection, genotype frequencies at any locus is a simple function of allele frequencies. Testing for HWE is now a common practice in population genetics and genetic association studies of non-communicable diseases; however, it is less-regarded, or sometimes miss-interpreted, i...
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متن کاملThe Essentiality of Reporting Hardy-Weinberg Equilibrium Calculations in Population-Based Genetic Association Studies
Population-based genetic association studies have proven to be a powerful tool in identifying genes implicated in many complex human diseases that have a huge impact on public health. An essential quality control step in such studies is to undertake Hardy-Weinberg equilibrium (HWE) calculations. Deviations from HWE in the control group may reflect important problems including selection bias, po...
متن کاملthe essentiality of reporting hardy-weinberg equilibrium calculations in population-based genetic association studies
population-based genetic association studies have proven to be a powerful tool in identifying genes implicated in many complex human diseases that have a huge impact on public health. an essential quality control step in such studies is to undertake hardy-weinberg equilibrium (hwe) calculations. deviations from hwe in the control group may reflect important problems including selection bias, po...
متن کاملBayesian methods for examining Hardy-Weinberg equilibrium.
Testing for Hardy-Weinberg equilibrium is ubiquitous and has traditionally been carried out via frequentist approaches. However, the discreteness of the sample space means that uniformity of p-values under the null cannot be assumed, with enumeration of all possible counts, conditional on the minor allele count, offering a computationally expensive way of p-value calibration. In addition, the i...
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ژورنال
عنوان ژورنال: Respirology
سال: 2011
ISSN: 1323-7799
DOI: 10.1111/j.1440-1843.2011.02063.x